Oxymetholone is a synthetic 17-alpha-alkylating anabolic steroid derivative of testosterone and its anabolic effects are used to treat muscle exhaustion in HIV patients.
The effects of testosterone in humans and other vertebrates are mediated by two main mechanisms: androgen receptor activation (either directly or as DHT) and conversion to estradiol and activation of certain estrogen receptors.
Free testosterone (T) is delivered to the cytoplasm by target tissue cells, where it can bind to the androgen receptor or be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so its androgenic activity is about 2.5 times greater than T.
Bodybuilding is such an engaged activity, including wide-ranging resistant workouts and weight lifting to add high quality muscle building features for aesthetic or competitive purposes. For this drive, some oral and injectable supplements are necessary for sufficient strength and mass gains.
Oxymetholone is an oral anabolic-androgenic steroid, fairly comparable to testosterone in its mechanism. It promotes massive muscle growth and development by stimulating comprehensive anabolic responses such as nitrogen balance and protein storage.
The active substance is oxymetholone. It dramatically enhances its efficacy if combined with a high calorie diet regimen. Oxymetholone is known to be a long acting drug with a reasonably gradual onset of action and sustained efficacy. It drastically improves appetite resulting in an abundant food intake and weight gain.
Oxymetholone is a good treatment option for diseases such as; anemia, muscle weakening and immune system failure. Apart from this, it is primarily a bulking agent that provides supreme support to the joints and connective tissues by an adequate collagen synthesis. The associated aromatization leads to the expression of estrogen effects in terms of fluid retention and muscle bulge.
The recommended daily dose in children and adults is 1-5 mg/kg of body weight per day. The usual effective dose is 1-2 mg/kg/day, but higher doses may be required and the dose should be adjusted individually.
The answer is not always immediate and should take at least three to six months. After remission, some patients may remain without the drug, others on the prescribed lower daily dose.
Long-term maintenance dose is usually needed in patients with congenital aplastic anemia.
Erythropoietic effects: Oral: 1 to 5 mg/kg/day once daily; usual effective dose: 1 to 2 mg/kg/day; give for a minimum trial of 3 to 6 months because response may be delayed
Fanconi anemia (off-label use): Limited data available: Oral: Initial: 2 mg/kg/day (median dose reported); most patients had a documented dose reduction although exact doses were not provided
Duration of therapy: 4.1 years (median for responders); 1.3 years (median for non-responders) (Paustian 2016). Additional data may be necessary to further define the role of oxymetholone in this condition.
Anadrol use could bring a rapid effect on your weight gain. Due to this, steady and short-term use is important. The standard use of this “juice” is 50 mg each day. Measuring dosage is easy since almost all Anadrol are sold in 50 mg tablets.
For beginners, the doses can start at 25 mg per day. If 50 mg tablet is all you can find, then take half a tab daily. In standardized use, 50 mg each day is used for the duration of three to four weeks. The dose is enough to give a result of fast body weight gain.
A low and steady dose of 25 mg per day is also used for the cutting cycle. There is also a high dosage, 75 to 100 mg per day is usually used for those who need faster body weight gain. However, a dose higher than 100 mg is not really necessary. Studies showed that even if someone takes more than 100 mg each day, there will be no particular difference in the result.